Mechanism by Which Magnesium Oxide Suppresses Tablet Hardness Reduction during Storage

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Mechanism by Which Magnesium Oxide Suppresses Tablet Hardness Reduction during Storage.

This study investigated how the inclusion of magnesium oxide (MgO) maintained tablet hardness during storage in an unpackaged state. Tablets were prepared with a range of MgO levels and stored at 40°C with 75% relative humidity for up to 14 d. The hardness of tablets prepared without MgO decreased over time. The amount of added MgO was positively associated with tablet hardness and mass from an...

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ژورنال

عنوان ژورنال: CHEMICAL & PHARMACEUTICAL BULLETIN

سال: 2016

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.c16-00021